Study of the structure-activity relationships of the acetogenin of annonaceae, muricatacin and analogues

Article abstract of DOI:10.1016/S0223-5234(97)83287-4

A study of the structure-cytotoxic activity of the acetogenin of Annonaceae, muricatacin 1, is reported. indeed, muricatacin 1 has shown promising antitumoral activity. Therefore several 5-hydroxy-4-alkcanolides were prepared and then tested against KB and VERO cell lines. A few other analogues were synthesized and tested against both cell lines. Thus this work allowed us to better determine the pharmacophore of the molecule and to propose muricatacin 1 instead of a more complicated acetogenin of Annonaceae as a lead compound in the search for new antineoplastic agents.