Studies of HIV-1 protease inhibitors. II. Incorporation of four types of hydroxyethylene dipeptide isosteres at the scissile site of substrate sequences

DOI: 10.1248/cpb.41.1378

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1378 - 1386 (1993)

Update date:2022-08-05

Topics: HIV-1 Protease Inhibitors studies Incorporation

Authors:

Sakurai Sakurai

Higashida

Sugano Sugano

Nishi Nishi

Saito Saito

Ohata Ohata

Handa Handa

Komai Komai

Yagi Yagi

Nishigaki

Yabe Yabe

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Article abstract of DOI:10.1248/cpb.41.1378

Human immunodeficiency virus type 1 (HIV-1) protease inhibitors containing four types of hydroxyethylene dipeptide isosteres were designed and synthesized. These inhibitors consist of eight stereoisomers of phenylalanylproline (Phe-Ψ[H.E.]-Pro), four ster

Full text of DOI:10.1248/cpb.41.1378

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