5-Heteroaryl-2'-deoxyuridine analogs. Synthesis and incorporation into high-affinity oligonucleotides

DOI: 10.1021/ja00092a003

Source and publish data:

Journal of the American Chemical Society p. 5540 - 5544 (1994)

Update date:2022-07-30

Topics: Synthesis Analog Oligonucleotides Incorporation High-Affinity

Authors:

Gutierrez

Terhorst

Matteucci

Froehler

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Article abstract of DOI:10.1021/ja00092a003

A series of C-5 heteroaryl-2'-deoxyuridines were synthesized from 5-iodo-2'-deoxyuridine. Palladium catalyzed coupling with heteroarylstannanes proved to be a convenient and general method of preparation. Oligonucleotides containing pyridine-, thiophene-,

Full text of DOI:10.1021/ja00092a003

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