Easy preparation of enantiopure C2-symmetrical aminoalcohols derived from m-xylylene diamine

Article abstract of DOI:10.1016/S0957-4166(00)80484-X

The title compounds were prepared by condensation of isophthaldehyde with chiral amino alcohols or α-amino esters in three different ways depending on the substitution pattern. These methods are: for N-substituted amino alcohols, by reduction of the epime