Novel Ligands Specific for Mitochondrial Benzodiazepine Receptors: 6-Arylpyrrolobenzothiazepine Derivatives. Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies

DOI: 10.1021/jm00036a007

Source and publish data:

Journal of Medicinal Chemistry p. 1427 - 1438 (1994)

Update date:2022-08-03

Topics:

Authors:

Fiorini, Isabella

Nacci, Vito

Ciani, Silvia Maria

Garofalo, Antonio

Campiani, Giuseppe

et al. et al.

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Article abstract of DOI:10.1021/jm00036a007

A novel class of ligands specific for MBR receptors has been identified: 6-arylpyrrolo<2,1-d><1,5>benzothiazepine derivatives.The majority of newly synthesized esters 37-64 as well as some intermediate ketones showed micro- or nanomolar affinity for <3H>P

Full text of DOI:10.1021/jm00036a007

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