The synthesis of modified achiral internucleoside linkages: -NHCH2CH2-linked oligonucleosides

DOI: 10.1016/S0040-4039(00)61716-1

Source and publish data:

Tetrahedron Letters p. 6017 - 6020 (1993)

Update date:2022-07-29

Topics:

Authors:

Saha, Ashis K.

Schairer, Wayne

Waychunas, Cheryl

Prasad Prasad

Sardaro, Mark

Upso, Donald A.

Kruse, Lawrence I.

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Article abstract of DOI:10.1016/S0040-4039(00)61716-1

A method for the synthesis of oligonucleosides uniformly linked by the NHCH₂CH₂ moiety is described. Syntheses of heterodimers and a thymidylate trimer along with relevant T and nuclease resistance data are described.

Full text of DOI:10.1016/S0040-4039(00)61716-1

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