Synthesis and antiviral evaluation of 2-mercapto-5,6- dichlorobenzimidazole-β-D-ribofuranonucleoside derivatives

Article abstract of DOI:10.1080/15257779408013253

2-Mercapto-5,6-dichlorobenzimidazole β-D-ribofuranonucleoside derivatives 8 - 10 have been synthesized and their antiviral properties examined. According to the glycosylation procedure used, the β-D-N-1 isomer (and the N,N-bis-riboside) or the β-D-S²-isomer have been obtained. All the prepared compounds were tested for their activity against a variety of RNA and DNA viruses, but they did not show significant antiviral activity.

Full text of DOI:10.1080/15257779408013253

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Synthesis and Antiviral Evaluation of 2-
Mercapto-5,6-dichlorobenzimidazole-β-
D-ribofuranonucleoside Derivatives
C. Mathé a , C. Périgaud a , G. Gosselin a & J.-L. Imbach a
a Laboratoire de Chimie Bio-Organique, U.R.A. n° 488 du C.N.R.S. ,
Université de Montpellier II , Sciences et Techniques du Languedoc,
case courrier 008, Place Eugéne Bataillon, 34095, Montpellier,
Cédex, 5, France
Published online: 23 Sep 2006.
To cite this article: C. Mathé , C. Périgaud , G. Gosselin & J.-L. Imbach (1994) Synthesis and
Antiviral Evaluation of 2-Mercapto-5,6-dichlorobenzimidazole-β-D-ribofuranonucleoside Derivatives,
Nucleosides and Nucleotides, 13:1-3, 437-446, DOI: 10.1080/15257779408013253
To link to this article: http://dx.doi.org/10.1080/15257779408013253
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