Reversal of regiochemistry in the synthesis of isoxazoles by nitrile oxide cycloadditions

DOI: 10.1016/S0040-4039(00)73248-5

Source and publish data:

Tetrahedron Letters p. 3589 - 3592 (1994)

Update date:2022-07-31

Topics: Synthesis Nitrile oxide Isoxazoles Cycloadditions Regiochemistry Experimental Reversal

Authors:

Easton Easton

Easton, Christopher J.

Hughes Hughes

Merricc Hughes

Tiekink Tiekink

Tiekink, Edward R. T.

Lubin Lubin

Lubin, Carolyn E.

Savage Savage

Paul Savage

Simpson Simpson

Simpson, Gregory W.

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Article abstract of DOI:10.1016/S0040-4039(00)73248-5

The isoxazolines 2a, 2b and 8 obtained from nitrile oxide cycloadditions to cyclohex-2-enone 1a and its analogues 1b and 7 reacted with nickel peroxide to give the isoxazoles 3a, 3b, and 9. In contrast, the correponding 2-bromocyclohex-2-enones 4a, 4b and

Full text of DOI:10.1016/S0040-4039(00)73248-5

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