Synthesis of Non-Racemic 5,5-Disubstituted 2-Cyclopentenones

Article abstract of DOI:10.1016/S0040-4039(00)61543-5

Chiral, non-racemic, bicyclic lactam 1 (X=Y=H) bearing an angular hydrogen at C-7a (1, R=H), underwent efficient diastereoselective dialkylation producing the quaternary substituted lactams 1 (X=Y=alkyl).The latter were transformed into carbinol amines 5