An Alkylative Strategy to the C-13 to C-21 Sector of Discodermolide

Article abstract of DOI:10.1016/S0040-4039(00)76205-8

An approach to the C-13 to C-21 sector if the immunosuppressive marine natural product discodermolide (1) is described.The C-15 to C-16 bond is formed by diastereoselective alkylation of a ketone enolate.Either diastereomer of alkylation can be obtained by selecting the appropriate counter ion.The C-16 to C-21 subunit is prepared in two steps from 11.