Synthesis and Structure - Activity Relationships of New Antitumor Taxoids. Effects of Cyclohexyl Substitution at the C-3'-and/or C-2 of Taxotere (Docetaxel)

Article abstract of DOI:10.1021/jm00042a013

Synthesis and cytotoxicity of the new analogs (11-13) of docetaxel possessing cyclohexyl groups instead of phenyl groups at the C-3' and/or C-2 benzoate positions are described. The C-2 cyclohexanecarboxylate analog of paclitaxel (15) is also synthesized