Semi-synthetic C23-substituted milbemycins via spiroacetal cleavage and resynthesis

DOI: 10.1016/0040-4039(94)85226-X

Source and publish data:

Tetrahedron Letters p. 2385 - 2388 (1994)

Update date:2022-08-05

Topics: Cleavage Semi-Synthetic Milbemycins spiroacetal

Authors:

Baker Baker

Baker, Geoffrey H.

Hudner Hudner

Hudner, Joseph F.

Hussain Hussain

Hussain, Nigel

Morgan Morgan

Morgan, David O.

Dorgan Dorgan

Dorgan, Roderick J. J.

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Article abstract of DOI:10.1016/0040-4039(94)85226-X

The lactone intermediates (2) and (3) are converted by lithium acetylide chemistry followed by mercury catalysed hydration to novel semi-synthetic 23-oxo C24 and C25 substituted milbemycins (7).

Full text of DOI:10.1016/0040-4039(94)85226-X

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