Enzymatic preparation of homochiral 2-(N-carbobenzyloxypiperid-4-yl)-1,3-propanediol monoacetate. A facile entry to both enantiomers of 3-hydroxymethylquinuclidine

Article abstract of DOI:10.1016/0957-4166(94)80012-X

Both enantiomers of monoacetate 1 have been prepared in high ee by lipase catalyzed monohydrolysis of the prochiral diacetate 3 and by monoacetylation of the corresponding diol 4.3-Hydroxymethylquinuclidine 2 was then synthesized in both enantiomeric form