Enzymatic preparation of homochiral 2-(N-carbobenzyloxypiperid-4-yl)-1,3-propanediol monoacetate. A facile entry to both enantiomers of 3-hydroxymethylquinuclidine

DOI: 10.1016/0957-4166(94)80012-X

Source and publish data:

Tetrahedron Asymmetry p. 537 - 540 (1994)

Update date:2022-08-03

Topics:

Authors:

Guanti Guanti

Banfi Banfi

Brusco Brusco

Narisano

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Article abstract of DOI:10.1016/0957-4166(94)80012-X

Both enantiomers of monoacetate 1 have been prepared in high ee by lipase catalyzed monohydrolysis of the prochiral diacetate 3 and by monoacetylation of the corresponding diol 4.3-Hydroxymethylquinuclidine 2 was then synthesized in both enantiomeric form

Full text of DOI:10.1016/0957-4166(94)80012-X

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