
Journal of Organic Chemistry p. 291 - 296 (1994)
Update date:2022-08-03
Topics:
Marson
Grabowska
Fallah
Walsgrove
Eggleston
Baures
δ-Lactams have been synthesized with excellent stereocontrol of substituents by condensing 3-alkenamides with aryl aldehydes in polyphosphoric ester. The scope of the condensation of 3-alkenamides with aryl aldehydes in several phosphate media is examined, and a rationale is proposed regarding γ-lactam versus δ-lactam formation.
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