First total synthesis of BE-12406 A

Article abstract of DOI:10.1016/S0040-4039(00)60738-4

A concise total synthesis of BE-12406 A (3a) was achieved. The key step was the selective O-glycosylation of naphthol 4 with L-rhamnopyranosyl fluoride 5, employing Cp₂HfCl₂-AgClO₄ in fluorobenzene at -20°C in the presence of a hindered base 9, affording O-glycoside 8 in good yield.