Quinolizidines. XXXIII. A chiral synthesis of (-)-ophiorrhizine, a pentacyclic quaternary indole alkaloid from ophiorrhiza major RIDL

DOI: 10.1248/cpb.43.49

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 49 - 52 (1995)

Update date:2022-08-04

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Authors:

Fujii Fujii

Ohba Ohba

Seto Seto

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Article abstract of DOI:10.1248/cpb.43.49

A detailed account is given of the first chiral synthesis of the Ophiorrhiza alkaloid ophiorrhizine [(-)-1]. The synthesis was started by coupling the lactim ether (+)-4, readily available from cincholoipon ethyl ester [(+)-3], with 6-benzyloxy-3-chloroac

Full text of DOI:10.1248/cpb.43.49

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