Chemical and Pharmaceutical Bulletin p. 49 - 52 (1995)
Update date:2022-08-04
Topics:
Fujii
Ohba
Seto
A detailed account is given of the first chiral synthesis of the Ophiorrhiza alkaloid ophiorrhizine [(-)-1]. The synthesis was started by coupling the lactim ether (+)-4, readily available from cincholoipon ethyl ester [(+)-3], with 6-benzyloxy-3-chloroac
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