Total synthesis of a novel immunosuppressant, myriomicin (thermozymocidin, ISP-I), and Z-myriocin

DOI: 10.1248/cpb.42.994

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 994 - 996 (1994)

Update date:2022-07-29

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Authors:

Yoshikawa

Yokokawa

Okuno Okuno

Murakami

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Article abstract of DOI:10.1248/cpb.42.994

Myriocin (thermozymocidin, ISP-I), which was known to exhibit several interesting biological properties such as potent immunosuppressive and antifungal activities, and a new analog Z-myriocin were synthesized from 2-deoxy-D-glucose. This synthetic pathway comprises a stereoselective formation of the chiral α,α-disubstituted amino acid structure in myriocin and Z-myriocin from the isopropylidene six-membered ketone by using a modified Darzen reaction as its key step.

Full text of DOI:10.1248/cpb.42.994

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