Discrimination of Spermidine Amino Functions by a New Protecting Group Strategy; Application to the Synthesis of Guanidinylated Polyamines, Including Hirudonine

Article abstract of DOI:10.1039/c39940002613

Agmatine and hirudonine, guanidine derivatives of putrescine and spermidine, respectively, are synthesised by the application of a new protecting group strategy for polyamines, which uses N-nitroguanidinyl as a precursor of guanidine functions and selectively blocks spermidine at N-1 and N-8 with trifluoroacetyl and at N-4 by 4-azidobenzyloxycarbonyl.