A Simple Enzymatic Synthesis of (3S,4R)-(+)-4-Hydroxy-3-phenyltetrahydroisoquinolines

Article abstract of DOI:10.1016/0957-4166(94)80127-4

An efficient versatile method is presented for the stereospecific synthesis of (+)-4-hydroxy-3-phenyltetrahydroisoquinolines 11 and 12 using (R)-arylcyanohydrins as the chiral starting material.From this asymmetric core, the synthetic process proceeds wit