CCK-A-Selective Tetrapeptides Containing Lys(Nε)-Amide Residues: Favorable in Vivo and in Vitro Effects of N-Methylation at the Aspartyl Residue

Article abstract of DOI:10.1021/jm00037a006

Previous structure-activity studies on a series of CCK-A selective tetrapeptide agonists, typified by A-71623 (Boc-Trp-Lys(CONH-Ph-o-Me)-Asp-(N-Me)Phe-NH2), have shown that replacement of the Lys(N^ε-carbamoyl) substituent with N^ε-acy