CCK-A-Selective Tetrapeptides Containing Lys(Nε)-Amide Residues: Favorable in Vivo and in Vitro Effects of N-Methylation at the Aspartyl Residue

DOI: 10.1021/jm00037a006

Source and publish data:

Journal of Medicinal Chemistry p. 1569 - 1571 (1994)

Update date:2022-08-03

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Authors:

Bennett, Michael J.

Nikkel, A. L.

Bianchi, Bruce R.

Miller, Thomas R.

Bednarz, Lisa

et al. et al.

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Article abstract of DOI:10.1021/jm00037a006

Previous structure-activity studies on a series of CCK-A selective tetrapeptide agonists, typified by A-71623 (Boc-Trp-Lys(CONH-Ph-o-Me)-Asp-(N-Me)Phe-NH2), have shown that replacement of the Lys(N^ε-carbamoyl) substituent with N^ε-acy

Full text of DOI:10.1021/jm00037a006

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