New Simple Laboratory Method for the Synthesis of Pirazidol

Article abstract of DOI:10.1007/BF00505759

5,6-Dihydro-8-methyl-4H-pyrazino<3,2,1-j,k>carbazole was obtained by the reaction of α-bromoacetaldehyde dibutylacetal, ammonium acetate, and 1,2,3,4-tetrahydro-6-methyl-1-ketocarbazole in acetic acid.The reduction of 5,6-dihydro-8-methyl-4H-pyrazino<3,2,1-j,k>carbazole or its hydrochloride with sodium borohydride leads to 2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazino<3,2,1-j,k>carbazole hydrochloride - the medicinal preparation pirazidol.