
Chemistry of Heterocyclic Compounds p. 1084 - 1085 (1983)
Update date:2022-08-03
Topics:
Grinev, A. N.
Krichevskii, E. S.
Romanova, O. B.
5,6-Dihydro-8-methyl-4H-pyrazino<3,2,1-j,k>carbazole was obtained by the reaction of α-bromoacetaldehyde dibutylacetal, ammonium acetate, and 1,2,3,4-tetrahydro-6-methyl-1-ketocarbazole in acetic acid.The reduction of 5,6-dihydro-8-methyl-4H-pyrazino<3,2,1-j,k>carbazole or its hydrochloride with sodium borohydride leads to 2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazino<3,2,1-j,k>carbazole hydrochloride - the medicinal preparation pirazidol.
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