Synthesis of optically active 1-fluoroalkyl benzenes

Article abstract of DOI:10.1016/S0040-4039(00)73178-9

A simple synthesis of optically active 1-fluoroalkyl benzenes bearing electron withdrawing substituents is developed. Optically active 1- hydroxyalkyl benzenes are converted into the methanesulfonates and subsequently converted into the optically active 1-fluoroalkyl benzenes 1 by use of the fluorinating agent cesium fluoride/N-methyl-formamide.