Chemoenzymatic synthesis of (2S,3R)-3-hydroxyproline from cyclopentadiene

DOI: 10.1016/0040-4039(94)88202-9

Source and publish data:

Tetrahedron Letters p. 6975 - 6976 (1994)

Update date:2022-08-03

Topics:

Authors:

Sundram, Hari

Golebiowski, Adam

Johnson, Carl R.

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Article abstract of DOI:10.1016/0040-4039(94)88202-9

Amido-alcohol 4, derived from cyclopentadiene and resolved using Candida antarctica lipase B-mediated transacetylation, was transformed to (2R,3R)-3-hydroxy-2-hydroxymethylpyrrolidine (2) and (2S,3R)-3-hydroxyproline (1).

Full text of DOI:10.1016/0040-4039(94)88202-9

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