Bioorganic and Medicinal Chemistry Letters p. 2253 - 2258 (1996)
Update date:2022-08-02
Topics:
Fisher, Liesl G.
Sher, Philip M.
Skwish, Stephen
Michel, Inge M.
Seiler, Steven M.
Dickinson, Kenneth E. J.
Novel heterocyclic β3 adrenergic receptor agonists were prepared and evaluated for their ability to bind to human β1, β2, and β3 adrenergic receptors. Stimulatory effects on the β3 adrenergic receptor were also measured. BMS-187257 (4b) was found to be a potent and selective β3 agonist.
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