Journal of Medicinal Chemistry p. 3051 - 3056 (1994)
Update date:2022-08-04
Topics: Chemical characterization Chemical Synthesis In vitro Testing In Vivo Testing Cancer Chemopreventive
Shealy, Y. Fulmer
Hosmer, Carla A.
Riordan, James M.
Wille, John W.
Rogers, Tina S.
Hill, Donald L.
The introduction of substituents at position 3 of methyl 4-oxoretinoate can be effected in good yields by alkylating the lithium dienolate.A second substituent can be introduced also, but the resulting 3,3-disubstituted-4-oxoretinoates were isolated in lo
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