
Tetrahedron p. 13739 - 13752 (1994)
Update date:2022-09-26
Topics:
Brown, Roger F. C.
Donohue, Andrew C.
Roy Jackson
McCarthy, Tom D.
The natural hydroxyamides, (-)-tembamide and (-)-aegeline, and the cardiac drug (-) -denopamine have been prepared in homochiral form in good overall yield (>65%) from para - methoxy or para-allyloxybenzaldehyde by synthetic sequences involving entantioselective hydrocyanation of the aldehydes. Similar chemistry has been used to prepare analogues of the bronchodilator (-)-salbutamol both in high yield and with good enantiomeric excess.
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Doi:10.1002/ejoc.201300800
(2014)Doi:10.1002/chem.201304615
(2014)Doi:10.1016/S0040-4039(00)78549-2
(1994)Doi:10.1039/DT9960000939
(1996)Doi:10.1002/jhet.1606
(2014)Doi:10.1021/ja500183z
(2014)