A facile preparation of 2- and 5-substituted 3-bromothiophenes

DOI: 10.1016/S0040-4039(00)78549-2

Source and publish data:

Tetrahedron Letters p. 9387 - 9390 (1994)

Update date:2022-09-26

Topics: Regioselectivity Column chromatography Catalyst Nucleophile Solvent Recrystallization Stirring Thiophene Bromination Isomer Workup Aromaticity Halogenation Reaction Monitoring Electrophilic Aromatic Substitution (EAS) Facile preparation Functional group Reaction yield NMR spectroscopy (Nuclear Magnetic Resonance)

Authors:

Masquelin

Obrecht Obrecht

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Article abstract of DOI:10.1016/S0040-4039(00)78549-2

Acetylenic ketones of type 4 and acetylenic acetals of type 6 (Scheme 1) are excellent cyclization precursors for the acid-catalyzed synthesis of various heterocycles. Using this methodology, 5- and 2-substituted 3-bromothiophenes of types 7 and 8 have be

Full text of DOI:10.1016/S0040-4039(00)78549-2

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