Stereocontrolled total synthesis of calcitriol derivatives: 1,25-Dihydroxy-2-(4'-hydroxybutyl)vitamin D3 analogs of an osteoporosis drug

DOI: 10.1021/jo00104a050

Source and publish data:

Journal of Organic Chemistry p. 7855 - 7861 (1994)

Update date:2022-08-04

Topics:

Authors:

Posner Posner

Johnson Johnson

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00104a050

The diastereomeric 2α- and 2β-(4'-hydroxybutyl) calcitriol analogs (-)-3 and (+)-3' were prepared in only 11 chemical operations, starting with 4 + 2-cycloaddition of commercially available methyl 2-pyrone-3-carboxylate. Highlights of this convergent and

Full text of DOI:10.1021/jo00104a050

Products guided by the article

Product name:C₂₈H₄₄O₂Si₂

Cas No:160557-86-8

R&D Labs maybe for 160557-86-8

Zhonghao (dalian) Research and Design Institute of Chemical Industry Co., Ltd

Contact:+86 411 84674606

Address:201, Huangpu Road , Shahekou District, Dalian ,116023-China
shanghai jiuling chemical co.,ltd.

Contact:+86-21-50387295

Address:Zaozhuang Road, Pudong, Shanghai City. China
hangzhou sunchem trading co., ltd.

Contact:13588470430--

Address:Room 406-407, the 4th Building, No549
Win-Win chemical Co.Ltd

website:http://www.win-winchemical.com

Contact:0086-577-64498589

Address:6F, No. 396 Xingping Road, Longwan Industrial Zone, Wenzhou City, Zhejiang, 325000 P.R.China
Haitong Chemical Industrial Co.,Ltd.

website:https://www.haitonglongwin.com/

Contact:+86-022-66221018

Address:18-701, No.99, The 4th Street, TEDA,

Relevant to this article

Dicarbonylbis<2-(diphenylphosphino)-N,N-dimethylethanamine>-bis-<μ-(2-methyl)-2-propanethiolato>dirhodium and dicarbonylbis<2-(diphenylphosphino)-N,N,N-trimethylethanaminium>-bis-<μ-(2-methyl)-2-propanethiolato>dirhodium tetraphenylborate. Their syntheses, characterization and....

Doi:10.1016/0022-328X(94)05015-4
(1995)
Self-assembly of Schiff-base palladacycle-based discrete pseudo-macrocycles: Evidence for hemilability of oxalate ligand

Doi:10.1016/j.jorganchem.2014.02.020
(2014)
Determination of the promoting effect of nano SiO₂ and H₃PO₄@nano SiO₂ in the thiocyanation of N-containing aromatic compounds under solvent-free conditions

Doi:10.1080/17415993.2015.1004066
(2015)
An expeditious approach to trisubstituted chiral tetrahydrofurans

Doi:10.1515/znb-2000-3-413
(2000)
Nucleophilic phosphine-catalyzed intramolecular michael reactions of N-allylic substituted α-amino nitriles: Construction of functionalized pyrrolidine rings via 5-endo-trig cyclizations

Doi:10.1021/jo500418s
(2014)
Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents

Doi:10.1016/j.ejmech.2017.11.070
(2018)

Article Doi