Stereocontrolled total synthesis of calcitriol derivatives: 1,25-Dihydroxy-2-(4'-hydroxybutyl)vitamin D3 analogs of an osteoporosis drug

DOI: 10.1021/jo00104a050

Source and publish data:

Journal of Organic Chemistry p. 7855 - 7861 (1994)

Update date:2022-08-04

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Authors:

Posner Posner

Johnson Johnson

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Article abstract of DOI:10.1021/jo00104a050

The diastereomeric 2α- and 2β-(4'-hydroxybutyl) calcitriol analogs (-)-3 and (+)-3' were prepared in only 11 chemical operations, starting with 4 + 2-cycloaddition of commercially available methyl 2-pyrone-3-carboxylate. Highlights of this convergent and

Full text of DOI:10.1021/jo00104a050

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