Approach to the Synthesis of Enantiomerically Pure Chatancin. I. Synthesis of (1R,2S,6S,7R,8S,3'S)-2-(4'-Benzyloxy-3'-methylbutoyl)-7-hydroxy-8-isopropyl-1-methylbicyclodecan-4-on

Article abstract of DOI:10.1007/BF00812715

Our first target on the way towards the synthesis of enantiomerically pure chatancin is the preparation of the title compound.The cycloadduct of 5,5-dimethoxy-1,2,3,4-tetrachlorocyclopentadiene and thymoquinone is stereo- and regioselectively reduced to t