Total synthesis of a frog poison, (±)-epibatidine, a potent non-opioid analgesic

DOI: 10.1248/cpb.42.1432

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1432 - 1436 (1994)

Update date:2022-07-31

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Authors:

Okabe Okabe

Natsume Natsume

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Article abstract of DOI:10.1248/cpb.42.1432

A non-opioid analgesic, epibatidine (1), isolated from Ecuadoran poison frogs was synthesized in the racemic form starting from a readily available compound 2. A partial Curtius rearrangement product 5 of 2 was converted into 12c by way of the ketone 3 an

Full text of DOI:10.1248/cpb.42.1432

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