Total synthesis of a frog poison, (±)-epibatidine, a potent non-opioid analgesic

DOI: 10.1248/cpb.42.1432

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1432 - 1436 (1994)

Update date:2022-07-31

Topics:

Authors:

Okabe Okabe

Natsume Natsume

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.42.1432

A non-opioid analgesic, epibatidine (1), isolated from Ecuadoran poison frogs was synthesized in the racemic form starting from a readily available compound 2. A partial Curtius rearrangement product 5 of 2 was converted into 12c by way of the ketone 3 an

Full text of DOI:10.1248/cpb.42.1432

NII-Electronic Library Service

Products guided by the article

Product name:methyl 3-(tert-butyloxycarbonyl)amino-7-(p-toluenesulfonyl)-7-azabicyclo<2.2.1>hept-2-ene-2-carboxylate

Cas No:160730-15-4

R&D Labs maybe for 160730-15-4

HANGZHOU FOREWIN PHARMA CO., LTD

Contact:+86-571-89053961

Address:hangzhou
ZHANGJIAGANG FREE TRADE ZONE YONG HAN INTERNATIONAL TRADING CO., LTD(expird)

Contact:86 512 57910558

Address:qianjin M road
Lianyungang Ningkang Chemical Co., Ltd

Contact:.+86-518-88588008

Address:http://www.chemnk.com
Jinan Finer Chemical Co., Ltd

website:http://www.finerchem.com

Contact:+86-531-88989536

Address:New Material Industry Park, Jinan Ciyt, China
UNION PHARMPRO CO.,LTD

Contact:18710867521(wechat)

Address:Rm10516,Galaxy Tech Building #2,No.25 Tangyan Rd,Hi-Tech Zone,Xi'an, China

Relevant to this article

S-(+)-Carvone as Starting Material in Synthesis (Part 4). Conjugate Addition of Cyanide and Grignard Nucleophiles Followed by Annulation to Functionalized Decalones.

Doi:10.1016/S0040-4020(01)89623-X
(1994)
Phthalimidesulfenyl Chloride Part 8. Reaction with Activated Arenes: the First Example of ortho-Thioquinones Generation

Doi:10.1016/S0040-4039(00)78568-6
(1994)
Phosphine-catalyzed asymmetric synthesis of β-lactones from disubstituted ketenes and aldehydes

Doi:10.1021/jo500486e
(2014)
Synthesis and structure of diethyl (1-benzyloxycarbonylamino-1-carboranyl- 3,3,3-trifluoropropyl)phosphonate

Doi:10.1007/s11172-013-0279-7
(2013)
NIS-mediated intramolecular oxidative α-functionalization of tertiary amines: Transition metal-free synthesis of 1,2-dihydro-(4H)-3,1-benzoxazin-4-one derivatives

Doi:10.1039/c5ra03882k
(2015)
Arylboration of internal alkynes by cooperative palladium/copper catalysis

Doi:10.1246/bcsj.20170226
(2017)

Article Doi