Chemistry Letters p. 2119 - 2122 (1994)
Update date:2022-09-26
Topics:
Takahashi, Shunya
Kuzuhara, Hiroyoshi
Aza-analog of the basic disaccharide unit in heparan sulfate was designed as a potential inhibitor against heparanase produced by solid tumor cells, and synthesized via a coupling reaction of a phenyl 2-azido-1-thio-D-glucopyranoside derivative with a partially protected 1-deoxynojirymycin derived from D-glucose, followed by manipulation such as imino acid formation, O-sulfation.
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