Catalyzed reaction of 2-methyl-1,3-dioxep-4-ene and halogen magnesium salts of secondary amines. A new approach to allylaminoalcohols

Article abstract of DOI:10.1016/S0040-4020(01)81214-X

In the presence of a catalytic amount of Ni°, 2-methyl-1,3-dioxep-4-ene (1) reacts with secondary halogen magnesioamides (2) to give mixtures of 4-aminobut-2-enols (3) and 2-aminobut-3-enols (4), arising from α- or γ-substitution to 1. The stereo and regiochemistry of the reaction is closely related to the structures of 2.