Solid-phase synthesis of peptidomimetic oligomers with a phosphodiesterase backbone

Article abstract of DOI:10.1016/S0960-894X(98)00064-X

An unnatural biopolymer is described in which amino acid side-chains are presented along a negatively charged phosphodiester backbone. For this purpose, a series of phosphoramidite monomers was prepared from chiral 1,2-diols. These were efficiently converted into oligomers using standard coupling conditions on an automated DNA synthesizer.