Journal of Medicinal Chemistry p. 3373 - 3382 (1994)
Update date:2022-07-30
Topics: Stereochemistry Alkyl Substituents Substitution Patterns Aromatic Ring Substituents Solubility and Pharmacokinetics
Kim, Hea Ok
Ji, Xiao-duo
Melman, Neli
Olah, Mark E.
Stiles, Gary L.
Jacobson, Kenneth A.
1,3-Dialkylxanthine analogues containing carboxylic acid and other charged groups on 8-position substituents were synthesized.These derivatives were examined for affinity in radioligand binding assays at rat brain A3 adenosine receptors stably
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