Synthesis and Antiretroviral Evaluation of 3-Alkyl 2-Piperazinone Nucleoside Analogs

DOI: 10.1016/0040-4039(94)88507-9

Source and publish data:

Tetrahedron Letters p. 9545 - 9548 (1994)

Update date:2022-08-05

Topics:

Authors:

Benjahad, Abdellah

Benhaddou, Rachida

Granet, Robert

Kaouadji, Mourad

Krausz, Pierre

et al. et al.

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Article abstract of DOI:10.1016/0040-4039(94)88507-9

Glycosylation of 3-alkyl N⁴-(3-hydroxypropyl) 2-piperazinones by ptotected 1-O-acetyl ribofuranoses produces nucleoside analogs in which the base is separated from the sugar by a hydrocarbon spacer arm.The preliminary in vitro test results against retroviruses seem promising for compounds bearing a long alkyl chain.

Full text of DOI:10.1016/0040-4039(94)88507-9

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