Journal of Antibiotics p. 722 - 757 (2002)
Update date:2022-08-03
Topics:
Sunagawa, Makoto
Itoh, Masanori
Kubota, Kubota
Sasaki, Akira
Ueda, Yutaka
Angehrn, Peter
Bourson, Anne
Goetschi, Erwin
Hebeisen, Paul
Then, Rudolf L.
Discovery of novel antimicrobial agents effective against infections caused by drug-resistant pathogens is an important objective. In order to find a new parenteral carbapenem antibiotic, which has potent antibacterial activity especially against methicillin-resistant staphylococci, vancomycin-resistant enterococci and penicillin-resistant Streptococcus pneumoniae, a series of 1β-methylcarbapenems with thiazol-2-ylthio groups at the C-2 position have been synthesized. Structure-activity relationships were investigated which led to SM-197436 (27), SM-232721 (44) and SM-232724 (41), being selected for further evaluation.
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