Synthesis and evaluation of novel pyrazolo[1,5-a]pyrimidine derivatives as nonpeptide angiotensin II receptor antagonists

DOI: 10.1248/cpb.43.960

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 960 - 965 (1995)

Update date:2022-08-03

Topics:

Authors:

Kiyama Kiyama

Hayashi Hayashi

Hara Hara

Fujimoto

Kawabata

Kawakami

Nakajima

Fujishita

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Article abstract of DOI:10.1248/cpb.43.960

A novel series of 6-alkyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid derivatives was prepared as angiotensin II (AII) receptor antagonists. When evaluated in an in vitro binding assay using COS cells transfected with a cDNA encoding a hu

Full text of DOI:10.1248/cpb.43.960

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Product name:6-Ethyl-7-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

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