A novel route to pyrimidine nucleosides via intramolecular couplings of bases with 2'-deoxyribosides: Quick and stereospecific...but with a 'twist'

Article abstract of DOI:10.1055/s-1994-25717

Coupling of a pyrimidine base (e.g., thymine) with the C-5' hydroxyl group of a 2'-deoxyriboside via bromoetherification leads to intermediates which can be converted to cyclonucleosides under the influence of Lewis acids. Ring opening by β-elimination af