The use of radical decarboxylation in the preparation of 1-methylcarbapenem antibiotic precursors from D-glucosamine

Article abstract of DOI:10.1016/S0957-4166(00)86289-8

The stereocontrolled synthesis of optically active 1-methylcarbapenams has been performed by radical cyclization and radical decarboxylation. 1,3,4-Trisubstituted 2-azetidinones, prepared by the Staudinger reaction with D-glucosamine as chiral auxiliary and sorbic acid were used as starting materials.