Selective C-2 and C-4 deacylation and acylation of taxol: The first synthesis of a C-4 substituted taxol analogue

Article abstract of DOI:10.1016/0040-4039(94)88392-0

Hydrolytic procedures for selective 2-debenzoylation and 2,4-dideacylation of 2'-O-tert-butyldimethylsilyl-7-O-(triethylsilyl)taxol are reported. The first synthesis and biological evaluation of a 4-substituted analogue, 4-deacetyl-4-isobutanoyltaxol, is