Synthesis of the taxol AB-system by olefination of an A-ring C1 ketone and direct B-ring closure

DOI: 10.1016/S0040-4020(97)00411-0

Source and publish data:

Tetrahedron p. 7139 - 7158 (1997)

Update date:2022-07-29

Topics:

Authors:

Crich, David

Natarajan, Swaminathan

Crich, Joyce Z.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(97)00411-0

Two syntheses of 13-deoxy-taxol C1 ketones are presented. Olefination of these C1 ketones is achieved, indirectly, via either the Meyer-Schuster reaction or by introduction of a vinyl group with vinylcerium dichloride followed by allylic rearrangement. Bo

Full text of DOI:10.1016/S0040-4020(97)00411-0

Products guided by the article

Product name:2,2,4-trimethyl-3-phenylthiomethyl-cyclohex-3-en-1-one

Cas No:162708-83-0

R&D Labs maybe for 162708-83-0

Quzhou Ruiyuan chemical Co., Ltd

Contact:+86-570-3039321/3039361/3039308

Address:18# Huayang Road,Quzhou High-tech Industrial Park, Zhejiang China.
Sichuan Highlight Fine Chemicals Co., Ltd.

Contact:+86-28-8525 1605

Address:A5-102 Airport base,388 West Airport Huang He Zhong Lu,2 Section
Hangzhou Haiqiang Chemical Co.,Ltd.

Contact:+86-571-86960370

Address:Add: 5/F, Around Town North Road,No. 10, Hangzhou, Zhejiang,China
Hangzhou Chemfar Ltd.

Contact:+86-571-87859231, 87859237, 87859239

Address:1606,Huarong Times Mansion, No.3880 Jiangnan Avenue, Binjiang District, Hangzhou, China, 310053
Hangzhou Taiyan Trading Co., Ltd(expird)

Contact:+86-13777583958

Address:NO.63, Xingyi Street, Xihu District, Hangzhou, Zhejiang, China

Relevant to this article

Doi:10.1021/jo01270a048
(1968)
Construction of AB-ring system of taxane framework by A-ring annulation strategy: Synthesis of 1-hydroxy-8,11,11-trimethylbicyclo[5.3.1]undec-7-en- 9-one by way of intramolecular aldol cyclization to form the C1-C10 bond

Doi:10.1248/cpb.45.1898
(1997)
An expeditious synthesis of structural analogs of the marine cytotoxic agents grossularines-1 and -2

Doi:10.1016/0040-4039(95)00323-5
(1995)
Synthesis and biological evaluation of novel urea-and guanidine-based derivatives for the treatment of obesity-related hepatic steatosis

Doi:10.3390/molecules19056163
(2014)
Synthesis of dibenzothiophenes by pd-catalyzed dual C-H activation from diaryl sulfides

Doi:10.1002/chem.201402265
(2014)
Efficient synthesis of chiral α,β-epoxyesters via a cyclic sulfate intermediate

Doi:10.1016/S0040-4039(98)00190-7
(1998)

Article Doi