Synthesis of the taxol AB-system by olefination of an A-ring C1 ketone and direct B-ring closure

DOI: 10.1016/S0040-4020(97)00411-0

Source and publish data:

Tetrahedron p. 7139 - 7158 (1997)

Update date:2022-07-29

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Authors:

Crich, David

Natarajan, Swaminathan

Crich, Joyce Z.

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Article abstract of DOI:10.1016/S0040-4020(97)00411-0

Two syntheses of 13-deoxy-taxol C1 ketones are presented. Olefination of these C1 ketones is achieved, indirectly, via either the Meyer-Schuster reaction or by introduction of a vinyl group with vinylcerium dichloride followed by allylic rearrangement. Bo

Full text of DOI:10.1016/S0040-4020(97)00411-0

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