Bioorganic and Medicinal Chemistry Letters p. 803 - 806 (1996)
Update date:2022-09-26
Topics:
Chapman, Kevin T.
Durette, Philippe L.
Caldwell, Charles G.
Sperow, Kelly M.
Niedzwiecki, Lisa M.
Harrison, Richard K.
Saphos, Cheryl
Christen, Amy J.
Olszewski, Julie M.
Moore, Vernon L.
MacCoss, Malcolm
Hagmann, William K.
Further development of N-carboxyalkyl dipeptide inhibitors of stromelysin-1 (MMP-3) led to the discovery of C-carboxyalkyl dipeptide analogs with improved oral bioavailability. An in vivo assay of human MMP-3 mediated degradation of a macromolecular substrate in an extravascular space is described and inhibition studies are reported.
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