Synthesis of taxol and taxotere side chains by 2-(trimethylsilyl)thiazole based homologation of L-phenylglycine

DOI: 10.1055/s-1995-3882

Source and publish data:

Synthesis p. 181 - 186 (1995)

Update date:2022-09-26

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Authors:

Dondoni Dondoni

Perrone Perrone

Semola Semola

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Article abstract of DOI:10.1055/s-1995-3882

L-Phenylglycine is homologated by the use of 2-(trimethylsilyl)thiazole into (2R,3S)-N-benzoyl- and N-tert-butoxycarbonyl-3-phenylisoserine, which are isolated as acetonide derivatives in 47 and 35% overall yields and with 84 and 90% ee, respectively.

Full text of DOI:10.1055/s-1995-3882

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