Stereospecific synthesis and NMR conformational studies of β-butyrolactones of nucleosides as chiral synthons for the preparation of 2'-C- and 3'-C-branched-chain nucleosides

Article abstract of DOI:10.1021/jo00104a021

A stereoselective method is described for the synthesis of [3.3.0] fused lactones (γ-butyrolactones) of ribonucleosides at the 2' and 3' positions of the furanose ring by intramolecular addition of radicals onto the α-position of α,β-unsaturated esters. A