Synthesis and biological activity of sugar-fluorinated 2',3'-dideoxy-4'- thioribofuranosyl nucleosides

Article abstract of DOI:10.1080/15257779508012426

The efficient DAST fluorination of deoxy-4'-thiopyrimidine nucleosides is reported. The cytidine analogue 3b was marginally effective against HIV.

Full text of DOI:10.1080/15257779508012426

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Nucleosides and Nucleotides
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Synthesis and Biological Activity of
Sugar-Fluorinated 2′,3′-dideoxy-4′-
thioribofuranosyl Nucleosides
Victor E. Marquez a , Lak S. Jeong a , Marc C. Nicklaus a & Cliff
George b
a Laboratory of Medicinal Chemistry, Developmental Therapeutics
Program, Division of Cancer Treatment , National Cancer Institute ,
NIH, Bethesda, Maryland, 20892
b Laboratory for the Structure of Matter, Naval Research
Laboratory , Washington, DC, 20375
Published online: 16 Feb 2007.
To cite this article: Victor E. Marquez , Lak S. Jeong , Marc C. Nicklaus & Cliff George (1995)
Synthesis and Biological Activity of Sugar-Fluorinated 2′,3′-dideoxy-4′-thioribofuranosyl Nucleosides,
Nucleosides and Nucleotides, 14:3-5, 555-558
To link to this article: http://dx.doi.org/10.1080/15257779508012426
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