Bioorganic and Medicinal Chemistry Letters p. 49 - 54 (2006)
Update date:2022-07-29
Topics:
Pereira, Raquel
Gaudon, Claudine
Iglesias, Beatriz
Germain, Pierre
Gronemeyer, Hinrich
De Lera, Angel R.
Sequential, position-selective, Pd-catalyzed cross-coupling reactions of 2,4-dibromo-5-hydroxymethylthiazole provided the scaffold for the synthesis of GW501516, the most potent PPARβ/δ agonist yet described, and equally selective analogs at the thiazole-
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