An efficient route to α,β-epoxy ketones of high enantiomerical purity

Article abstract of DOI:10.1055/s-1994-25700

Acylepoxides were obtained in high enantiomeric purity (ee = 92-99%) by addition of organolithium or Grignard reagents to enantiomerically pure methyl or ethyl 2,3-epoxypropanoates at low temperature (-85°C).