Chemistry of Extradiol Aromatic Ring Cleavage: Isolation of a Stable Dienol Ring Fission Intermediate and Stereochemistry of Its Enzymatic Hydrolytic Cleavage

DOI: 10.1039/c39940001163

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1163 - 1164 (1994)

Update date:2022-08-03

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Authors:

Lam, Winnie W. Y.

Bugg, Timothy D. H.

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Article abstract of DOI:10.1039/c39940001163

The meta-ring fission intermediate on the phenylpropionate catabolic pathway exists as a stable trans-dienol; its breakdown by hydrolase enzyme MhpC proceeds with overall replacement of the succinyl group by a proton from water with retention of stereochemistry.

Full text of DOI:10.1039/c39940001163

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