Partial GABAA Receptor Agonists. Synthesis and in Vitro Pharmacology of a Series of Nonannulated Analogs of 4,5,6,7-Tetrahydroisoxazolopyridin-3-ol

DOI: 10.1021/jm00017a014

Source and publish data:

Journal of Medicinal Chemistry p. 3287 - 3296 (1995)

Update date:2022-07-30

Topics:

Authors:

Froelund, Bente

Kristiansen, Uffe

Brehm, Lotte

Hansen, Annette B.

Krogsgaard-Larsen, Povl

Falch, Erik

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Article abstract of DOI:10.1021/jm00017a014

5-(4-Piperidyl)isoxazol-3-ol (4-PIOL, 10), a structural analog of 4-aminobutanoic acid (GABA, 1) and the GABA_A agonist 4,5,6,7-tetrahydroisoxazolo<5,4-c>pyridin-3-ol (THIP, 5), is a low-efficiacy partial GABA_A agonist.A number of com

Full text of DOI:10.1021/jm00017a014

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