Partial GABAA Receptor Agonists. Synthesis and in Vitro Pharmacology of a Series of Nonannulated Analogs of 4,5,6,7-Tetrahydroisoxazolopyridin-3-ol

DOI: 10.1021/jm00017a014

Source and publish data:

Journal of Medicinal Chemistry p. 3287 - 3296 (1995)

Update date:2022-07-30

Topics:

Authors:

Froelund, Bente

Kristiansen, Uffe

Brehm, Lotte

Hansen, Annette B.

Krogsgaard-Larsen, Povl

Falch, Erik

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00017a014

5-(4-Piperidyl)isoxazol-3-ol (4-PIOL, 10), a structural analog of 4-aminobutanoic acid (GABA, 1) and the GABA_A agonist 4,5,6,7-tetrahydroisoxazolo<5,4-c>pyridin-3-ol (THIP, 5), is a low-efficiacy partial GABA_A agonist.A number of com

Full text of DOI:10.1021/jm00017a014

Products guided by the article

Product name:4-[3-(4-Methoxy-benzyloxy)-isoxazol-5-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid 1-chloro-ethyl ester

Cas No:167414-83-7

R&D Labs maybe for 167414-83-7

Shanxi Sanwei Group Co.,Ltd

Contact:0086-357-6662688

Address:Zhaocheng town, Hongtong County, Linfen City, Shanxi Province
FREEBARQUE DEVELOPMENT GROUP LIMITED

Contact:+86(0)10-5109 5335 or 5109 5345

Address:Room602,Block1-B,LINGDI OFFICE,NO.13 BEIYUAN ROAD
SHANGHAI T&W PHARMACEUTICAL CO., LTD.

website:http://www.trustwe.com

Contact:+86-21-61551413

Address:601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong
Shandong Topscience Biotech Co., Ltd.

Contact:0633-2619278

Address:No. 98 Lanshan West Road, Lanshan District, Rizhao, Shandong Province, P.R. of China
Changsha Huajing Powdery Material Technological Co., Ltd.

Contact:86-731-88879686

Address:Building 2, West Garden, Main Campus of Central South University, Changsha, Hunan Province, China

Relevant to this article

Doi:10.1021/ja00994a055
(1967)
Possibility of applying the electrochemical version of the Horner reaction to the synthesis of unsaturated lactones

Doi:10.1007/BF00699993
(1993)
On the Reaction Pathway and Stereochemistry of Allylic Tin Reagents-Benzaldehyde Condensation. A Substituent Effect Study

Doi:10.1246/cl.1990.1711
(1990)
Eight new C-21 steroidal glycosides from Dregea sinensis var. corrugata

Doi:10.1016/j.steroids.2007.03.002
(2007)
Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors

Doi:10.1016/j.bmcl.2008.05.077
(2008)
Diastereoisomerically Pure Dinucleosidylphosphorofluoridites and their Application in Stereospecific Synthesis of Dinucleosidylphosphorofluoridothionates

Doi:10.1039/c39950001435
(1995)

Article Doi