The Synthesis of 4-Acetoxy-azetidin-2-ones as Key Intermediates for β-Lactams

DOI: 10.1016/0040-4020(95)00542-G

Source and publish data:

Tetrahedron p. 9523 - 9530 (1995)

Update date:2022-08-06

Topics:

Authors:

Kehagia, Konstantina

Ugi, Ivar K.

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Article abstract of DOI:10.1016/0040-4020(95)00542-G

A short synthesis of a chiral precursor of a cephem derivative is described.Starting material is the inexpesive chiral-pool chemical aspartic acid.The central step in forming the β-lactam moiety is an Ugi reaction.

Full text of DOI:10.1016/0040-4020(95)00542-G

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